Gestational Trophoblastic Disease/Complete h-mole

§Hydatidiform mole

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§Incomplete or partial mole

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§Coexisting mole and fetus

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§Invasive mole

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§Choriocarcinoma

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Complete mole 

-Fertilization an empty egg by one sperm.

-All placental villa swollen.

-Fetus, cord, amniotic membrane are absent.

-Paternal chromosomes only. 46 XX.

-diploidy

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incomplete mole 

-fertilization of an egg by

  two sperms

-some placental villa swollen

    Fetus, cord, amniotic 

    membrane are present

-Paternal and maternal 69XXY

-Triploid

 

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◦Heavy Vaginal bleeding, excessive vomiting, & high BP .

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◦a large-for-date uterus with “swiss cheese” endometrium

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◦Serum HCG titers will be markedly elevated.

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◦Large cysts may be seen in the ovaries : theca lutein cysts

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Complete h-mole

Most common type of GTN

(GTN, also known as choriocarcinoma).

Proliferative growth of trophoblastic tissue

May become invasive or metastatic : invasive mole, chriocarcinoma