Down Syndrome Down Syndrome Cause: In most cases, Down syndrome occurs when there is an extra copy of chromosome 21. This form of Down syndrome is called Trisomy 21. Primarily Affects: Equal frequency for males and females. Discovered By: Dr. John Langdon Down Symptoms: Symptoms of Down Syndrome include small ears, small mouth, upward slanting eyes, flattened nose, decreased muscle tone at birth, wide hands, .. 2014. 6. 17. 이전 1 다음