holt-oram syndrome Holt-Oram syndrome, also known as heart-hand syndrome, is an autosomal dominant disorder, with complete penetrance and very variable expression, and a prevalence of 1 in 100,000 live births (24). The syndrome is characterized by cardiac anomalies in fetuses with upper limb deformities.Preaxial radial ray malformations occur in all affected fetuses and is required for the diagnosis.Cardiac anomal.. 2020. 5. 3. 이전 1 2 다음